Gene Expression Profile classification and Meaningful Discovery using Non-Negative Matrix Factorization

Maqsood Hayat, Nadeem Iqbal, Mohammad Sohail, Muhammad Noman Hayat

Abstract


Accurate Classification of cancer types or subtypes is a great importance for better treatment and prognosis. With advent of microarray technology, which can simultaneously monitor the expression of all genes in the genome, can be used to diagnosis and classify cancer types in a systematic and objective fashion.  In this paper we propose a model for classification of microarray data through Non-Negative Matrix Factorization (NMF).The NMF is explored as feature extraction and K- Nearest Neighbor (KNN) is utilized as classification algorithm to classify the cancer disease for microarray dataset. The NMF approach is based on decomposition by parts one of them is the ‘encoding matrix’ contains the sample information that helps to classify the samples according to the similar gene expression labels and other factor ‘basis matrix’ that contains the gene expression label that helps to reduced the dimension and discovery of meaningful genes for a certain disease. Two benchmark datasets, Leukemia and Colon datasets are used to evaluate the proposed model. The proposed model achieved quite promising accuracy 97% on Leukemia dataset and 91% on Colon dataset. In addition, NMF also used to exhibits the meaningful genes that useful for the classification of the cancer related microarray data.


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